Nom du corpus

Corpus Systématique Animale

Titre du document

Linkage between complement components 6 and 7 and glutamic pyruvate transaminase in the marsupial Monodelphis domestica

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • complement factor
  • polymorphism
  • gene mapping
  • linkage
  • opossum
Nom du fichier dans la ressource
Mammiferes_v2b_02759
Auteur(s)
  • Roland A. H. van Oorschot 1
  • Virginia Birmingham 1
  • Patricia A. Porter 1
  • Candace M. Kammerer 1
  • John L. VandeBerg 1
Affiliation(s)
  • 1) Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 28147, 78228-0147, San Antonio, Texas
Résumé

The sixth and seventh components of complement were found to be polymorphic and tightly linked in the laboratory opossum (Monodelphis domestica), as they are in eutherian mammals. In addition, strong evidence for linkage of theC6–C7 haplotype to the gene for glutamic pyruvate transaminase (GPT) was obtained for females but not for males. This result, combined with previous observations, establishes as a generality that recombination is severely reduced in females of this species by comparison with males. It also establishes synteny ofC6–C7 andGPT in a marsupial species, as exists in mice. Because these loci are not syntenic in humans, the results imply that this synteny is ancestral to the separation of marsupials and eutherians and that it was broken relatively recently in the mammalian lineage leading to human beings. The newly described C6 and C7 polymorphisms provide additional power for developing a linkage map for M. domestica and for localizing genes that confer susceptibility to diseases for which this species is used as a model.

Catégories Science-Metrix
  • 1 - natural sciences
  • 2 - biology
  • 3 - evolutionary biology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Molecular Biology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
  • 1 - Life Sciences ; 2 - Agricultural and Biological Sciences ; 3 - Ecology, Evolution, Behavior and Systematics
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Biochemistry
Catégories WoS
  • 1 - science ; 2 - genetics & heredity
  • 1 - science ; 2 - biochemistry & molecular biology
Identifiant ISTEX
3136653D61166C4D6C6100C80901BF6D9942FB59
Revue

Biochemical Genetics

Année de publication
1993
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
6.911
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-K5LBL6L5-K
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