Nom du corpus

Corpus Systématique Animale

Titre du document

Characterization of the MHC class II region in cattle. The number of DQ genes varies between haplotypes

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Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Mammiferes_v2b_02115
Auteur(s)
  • Leif Andersson 1
  • Lars Rask 2
Affiliation(s)
  • 1) Department of Animal Breeding, Swedish University of Agricultural Sciences, Biomedical Centre, Box 596, S-751 24, Uppsala, Sweden
  • 2) Department of Cell Research, Swedish University of Agricultural Sciences, Biomedical Centre, Box 596, S-751 24, Uppsala, Sweden
Résumé

The organization of the major histocompatibility complex (MHC) class II region in cattle was investigated by Southern blot analysis using human probes corresponding to DO, DP, DQ, and DR genes. Exon-specific probes were also employed to facilitate the assessment of the number of different bovine class II genes. The results indicated the presence of single DO ?and DR ?genes, at least three DR ?genes, while the number of DQ genes was found to vary between MHC haplotypes. Four DQ haplotypes, DQ ? 1 ? 1 to DQ ? 2 ? 4, possessed a single DQ ? and a single DQ ?gene whereas both these genes were duplicated in eight other haplotypes, DQ ? 3 ? 5 to DQ ? 9 ? 12. No firm evidence for the presence of bovine DP genes was obtained. The same human probes were also used to investigate the genetic polymorphism of bovine class II genes. DQ? DQ ? , DR? DR ? , and DO ? restriction fragment length polymorphisms (RFLPs) were resolved and in particular the DQ restriction fragment patterns were highly polymorphic. Comparison of the present result with the current knowledge of the class II region in other mammalian species suggested that the DO, DP, DQ, DR, and DZ subdivision of the class II region was established already in the ancestor of mammals. The DP genes appear to be the least conserved class II genes among mammalian species and may have been lost in cattle. The degree of polymorphism of different class II genes, as revealed by RFLP analyses, shows striking similarities between species.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - immunology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
  • 1 - Life Sciences ; 2 - Immunology and Microbiology ; 3 - Immunology
Catégories WoS
  • 1 - science ; 2 - immunology
  • 1 - science ; 2 - genetics & heredity
Identifiant ISTEX
6E3E44F1F9321F5E9F4B21195F7AFEE84468BFC3
Revue

Immunogenetics

Année de publication
1988
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
10
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-JH3NXSWG-4
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