Nom du corpus

Corpus Systématique Animale

Titre du document

Species differences in the immunophenotype of osteoclasts and mononuclear phagocytes

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • Osteoclast
  • Macrophage
  • Monocyte
  • Monoclonal antibody
Nom du fichier dans la ressource
Mammiferes_v2b_00410, Oiseaux_v2b_00486
Auteur(s)
  • N. A. Athanasou 1
  • J. I. Alvarez 2
  • F. P. Ross 2
  • J. M. Quinn 1
  • S. L. Teitelbaum 2
Affiliation(s)
  • 1) Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital, OX3 9DU, Headington, Oxford, UK
  • 2) Department of Pathology and Laboratory Medicine, Jewish Hospital, Washington University School of Medicine, 63110, St. Louis, MO, USA
Résumé

Human osteoclasts, in contrast to mononuclear phagocytes, are known to express a well-defined restricted range of myeloid antigens. To determine whether these antigenic differences are present in other species, we examined the immunophenotype of chicken and rabbit ostoeclasts, macrophages, macrophage polykaryons, and monocytes and compared them with similarly derived and cultured human cells. Human, rabbit, and avian osteoclasts reacted with monoclonal antibodies against human ?1 integrins (CD29, CD49b, CD49d), ?3 integrins (CD51, CD61), as well as human macrophage-associated antigen CD68. Avian osteoclasts also reacted for CD11a/18 and CD14 which are not present on human osteoclasts. Avian and mammalian monocytes, macrophages, and macrophage polykaryons expressed all the above antigens. Both avian and human macrophage polykaryons produced by culture of peritoneal macrophages reacted with anti-CD51 antibodies indicating that expression of the vitronectin receptor alone does not distinguish between these cells in vitro.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - endocrinology & metabolism
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - vertebres: systeme osteoarticulaire, muscle strie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Endocrinology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Orthopedics and Sports Medicine
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Endocrinology, Diabetes and Metabolism
Catégories WoS
  • 1 - science ; 2 - endocrinology & metabolism
Identifiant ISTEX
8076C90B08017CDD9EBE632910E6611D6559D249
Revue

Calcified Tissue International

Année de publication
1992
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
7.633
Sous-corpus
  • Mammiferes
  • Oiseaux
Type de publication
Journal
ark:/67375/1BB-JFKTN0Z7-6
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