Nom du corpus

Corpus Systématique Animale

Titre du document

Microbial Biotransformation of Retinoic Acid by Cunninghamella echinulata and Cunninghamella blakesleeana

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • retinoic acid
  • metabolism
  • microbial models
  • retinoids
  • chemoprevention
Nom du fichier dans la ressource
Mammiferes_v2b_02620
Auteur(s)
  • David A. Hartman 1
  • Jack B. Basil 1
  • Larry W. Robertson 1
  • Robert W. Curley Jr. 1
Affiliation(s)
  • 1) Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 43210, Columbus, Ohio
Résumé

Vitamin A (retinol) is needed by higher animals for the maintenance of normal epithelium and growth, and retinoic acid (1) has been proposed to be the active metabolite. Microbial models are useful for the study of mammalian metabolism of xenobiotics. Two species of the fungal genus Cunninghamella afforded products of greater polarity than 1 when fed 1 in a two-stage fermentation procedure. The products obtained were principally the result of oxidation of the trimethylcyclohexenyl ring. Although most of the isolated metabolites of 1 have been previously seen in mammalian studies, two novel compounds, 2-hydroxyretinoic acid (2) and 2,3-dehydro-4-oxoretinoic acid (4), were isolated.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - pharmacology & pharmacy
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Pharmacology (medical)
  • 1 - Physical Sciences ; 2 - Chemistry ; 3 - Organic Chemistry
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - Pharmaceutical Science
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - Pharmacology
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Molecular Medicine
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Biotechnology
Catégories WoS
  • 1 - science ; 2 - pharmacology & pharmacy
  • 1 - science ; 2 - chemistry, multidisciplinary
Identifiant ISTEX
08AAC0AD657FF7D0923058EFBCE8A06657641FEA
Revue

Pharmaceutical Research

Année de publication
1990
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
3.286
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-H7C26WFS-3
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