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Corpus Systématique Animale

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Different evolution rates within the lens-specific ? -crystallin gene family

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Springer (journals)
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  • ?-crystallins
  • ?-crystallins
  • Lens
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  • Henk J. M. Aarts 1
  • Eldine H. M. Jacobs 1
  • Gijsbert van Willigen 1
  • Nicolette H. Lubsen 1
  • John G. G. Schoenmakers 1
  • 1) Laboratory of Molecular Biology, University of Nijmegen, Toernooiveld, 6525 ED, Nijmegen, The Netherlands

We have determined the sequence of a rat ?A3/A1-crystallin complementary DNA (cDNA) clone and the (partial) sequence of the human ?B3-crystallin gene. Calculation of the ratio of silent to nonsynonymous substitution between orthologous ?A3/A1-, ?B3-, and other ?- and ?-crystallin sequences revealed that the region encoding the two globular domains of the ?A3/A1-crystallin sequence is the best conserved during evolution, much better than the corresponding region of the ?B1-, ?B3-, or the ?-crystallin sequences, and even better (at least in the rodent/frog comparison) that the well-conserved ?A-crystallin sequence. Remarkably, the rate of change of the ?A3/A1-crystallin coding sequence does not differ in the rodent and primate lineages, in contrast with previous findings concerning the evolution rates of the ?A- or ?-crystallin sequences in these two lineages. Comparison of the regions that encode the four motifs of the ?-crystallin between orthologous mammalian sequences showed that the extent of nonsynonymous substitution in each of these four homologous motif regions is the same. However, when the orthologous ?-crystallin genes of more distantly related species (mammals vs chicken or frog) are compared, the extent of nonsynonymous substitution is higher in the regions encoding the external motifs I and III than in the regions encoding the internal motifs II and IV. This phenomenon is also observed when paralogous members of the ?/?-crystallin supergene family are compared.

Catégories Science-Metrix
  • 1 - natural sciences
  • 2 - biology
  • 3 - evolutionary biology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Molecular Biology
  • 1 - Life Sciences ; 2 - Agricultural and Biological Sciences ; 3 - Ecology, Evolution, Behavior and Systematics
Catégories WoS
  • 1 - science ; 2 - genetics & heredity
  • 1 - science ; 2 - evolutionary biology
  • 1 - science ; 2 - biochemistry & molecular biology
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Journal of Molecular Evolution

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  • Mammiferes
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