Nom du corpus

Corpus Systématique Animale

Titre du document

Generation and reactivation of T-cell receptor A joining region pseudogenes in primates

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Mammiferes_v2b_02750
Auteur(s)
  • Cornelia Thiel 1
  • Nel Otting 2
  • Ronald E. Bontrop 2
  • Jerry S. Lanchbury 1
Affiliation(s)
  • 1) Molecular Immunogenetics Unit, Division of Medicine, UMDS, 4th Floor Hunt's House, Guy's Hospital, SE1 9RT, London, UK
  • 2) Department of Immunology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
Résumé

Tandemly duplicated T-cell receptor (Tcr) AJ (J?) segments contribute significantly to TCRA chain junctional region diversity in mammals. Since only limited data exists on TCRA diversity in nonhuman primates, we examined the TCRAJ regions of 37 chimpanzee and 71 rhesus macaque TCRA cDNA clones derived from inverse polymerase chain reaction on peripheral blood mononuclear cell cDNA of healthy animals. Twenty-five different TCRAJ regions were characterized in the chimpanzee and 36 in the rhesus macaque. Each bears a close structural relationship to an equivalent human TCRAJ region. Conserved amino acid motifs are shared between all three species. There are indications that differences between nonhuman primates and humans exist in the generation of TCRAJ pseudogenes. The nucleotide and amino acid sequences of the various characterized TCRAJ of each species are reported and we compare our results to the available information on human genomic sequences. Although we provide evidence of dynamic processes modifying TCRAJ segments during primate evolution, their repertoire and primary structure appears to be relatively conserved.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - immunology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - genetique des eucaryotes. evolution biologique et moleculaire
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
  • 1 - Life Sciences ; 2 - Immunology and Microbiology ; 3 - Immunology
Catégories WoS
  • 1 - science ; 2 - immunology
  • 1 - science ; 2 - genetics & heredity
Identifiant ISTEX
7D7A05AE32DB9F4B30CF60F7F67C1FCCF7D8E80C
Revue

Immunogenetics

Année de publication
1995
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
8.98
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-C5LG1WZR-W
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