Nom du corpus

Corpus Systématique Animale

Titre du document

Fungal Metabolism of 4-Methylprimaquine

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • 4-methylprimaquine, fungal metabolism
  • 8-aminoquinoline, metabolism
  • Aspergillus ochraceus , 4-methylprimaquine metabolism
Nom du fichier dans la ressource
Mammiferes_v2b_00360
Auteur(s)
  • Alice M. Clark 1
  • James D. McChesney 1
  • Charles D. Hufford 1
Affiliation(s)
  • 1) Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, 38677, University, Mississippi
Résumé

4-Methylprimaquine (4-MPQ), an 8-aminoquinoline antimalarial drug, was subjected to microbial metabolism studies in an effort to isolate, identify, and predict the probable mammalian metabolite(s). Preliminary screening with a number of strains of Aspergillus indicated that several species were capable of metabolizing 4-MPQ to one major metabolite based on thin-layer chromatographic analysis. Preparative scale conversion of 4-MPQ using whole-cell suspensions of Aspergillus ochraceus afforded one major metabolite (4-MPQ-I). Based on spectroscopic and chemical evidence, the structure of the metabolite is proposed as 6-methoxy-8-(3-carboxyl-l-methylpropylamino)-lepidine.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - pharmacology & pharmacy
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Pharmacology (medical)
  • 1 - Physical Sciences ; 2 - Chemistry ; 3 - Organic Chemistry
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - Pharmaceutical Science
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - Pharmacology
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Molecular Medicine
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Biotechnology
Catégories WoS
  • 1 - science ; 2 - pharmacology & pharmacy
  • 1 - science ; 2 - chemistry, multidisciplinary
Identifiant ISTEX
BBB4E26E8B9182D416424D8E6FBDAC9317601D49
Revue

Pharmaceutical Research

Année de publication
1986
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
3.046
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-BGCFT7XM-2
Powered by Lodex 9.3.8