Nom du corpus

Corpus Systématique Animale

Titre du document

Ochratoxin A in human blood and Balkan endemic nephropathy

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • Ochratoxin A
  • Kidney disease
Nom du fichier dans la ressource
Mammiferes_v2b_00262
Auteur(s)
  • Karl Hult 1
  • Radovan Pleština 2
  • Vlasta Habazin-Novak 2
  • Božica Radi? 2
  • Stjepan ?eovi? 3
Affiliation(s)
  • 1) Department of Biochemistry and Biotechnology, Royal Institute of Technology, S-100 44, Stockholm, Sweden
  • 2) Institute for Medical Research and Occupational Health, M. Pijade 158, P.O. Box 291, Y-4100 1, Zagreb, Yugoslavia
  • 3) Department of Epidemiology, Medical Centre, Slavonski Brod, Yugoslavia
Résumé

The etiology of Balkan endemic nephropathy, a kidney disease encountered among the rural population living in regions along several big rivers on the Balkan Peninsula, remains unknown in spite of many hypotheses put forward and tested. One hypothesis involves mycotoxins as the causal agent. The mycotoxin ochratoxin A has been demonstrated to have a potent nephrotoxic effect in all mammalian species tested so far. The results of analysis of ochratoxin A in human blood samples by an analytical method based on the measurement of fluorescence spectra, before and after incubation with carboxypeptidase A, is described. For a 2-g-sample the detection limit of the method is 1–2 ng/g serum. High performance liquid chromatography used for the confirmation of ochratoxin A identity by means of several derivatives of the molecule is also described. Out of more than 600 samples collected in an endemic region in Yugoslavia about 7% were positive for ochratoxin A. The highest concentration found was 40 ng ochratoxin A/g serum.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - toxicology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences medicales
Catégories Scopus
  • 1 - Physical Sciences ; 2 - Environmental Science ; 3 - Health, Toxicology and Mutagenesis
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - Toxicology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
Catégories WoS
  • 1 - science ; 2 - toxicology
Identifiant ISTEX
9F5201AC774DCC40002B7A6174D0D82A7F1C295A
Revue

Archives of Toxicology

Année de publication
1982
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
7.782
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-B1M0R5LC-D
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