Nom du corpus

Corpus Systématique Animale

Titre du document

Phylogeny of immunoglobulin heavy chain isotypes: structure of the constant region of Ambystoma mexicanum ? chain deduced from cDNA sequence

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Batraciens_v2b_00248, Mammiferes_v2b_01267, Oiseaux_v2b_01330
Auteur(s)
  • Julien S. Fellah 1
  • Fabienne Kerfourn 1
  • Michael V. Wiles 2
  • Joseph Schwager 2,3
  • Jacques Charlemagne 1
Affiliation(s)
  • 1) Groupe d'Immunologie Comparée, Université Pierre et Marie Curie and Centre National de la Recherche Scientifique (URA 1135), 9 quai Saint-Bernard, F-75 230, Paris Cédex 05, France
  • 2) Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005, Basel, Switzerland
  • 3) Centre de Recherche sur la Nutrition et la Santé Animale, Roche S. A., F-68305, Saint-Louis Cédex, France
Résumé

An RNA polymerase chain reaction strategy was used to amplify and clone a cDNA segment encoding for the complete constant part of the axolotl IgY heavy (C?) chain. C? is 433 amino acids long and organized into four domains (C?1–C?4); each has the typical internal disulfide bond and invariant tryptophane residues. Axolotl C? is most closely related to Xenopus C? (40% identical amino acid residues) and C?1 shares 46.4% amino acid residues among these species. The presence of additional cysteines in C?1 and C?2 domains is consistent with an additional intra-domain S-S bond similar to that suggested for Xenopus C? and C?, and for the avian C? and the human C?. C?4 ends with the Gly-Lys dipeptide characteristic of secreted mammalian C?3, human C?4, and avian and anuran C?4, and contains the consensus [G/GT(AA)] nucleotide splice signal sequence for joining C?4 to the transmembrane region. These results are consistent with the hypothesis of an ancestral structural relationship between amphibian, avian ? chains, and mammalian ? chains. However, these molecules have different biological properties: axolotl IgY is secretory Ig, anuran and avian IgY behave like mammalian IgG, and mammalian IgE is implicated in anaphylactic reactions.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - immunology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
  • 1 - Life Sciences ; 2 - Immunology and Microbiology ; 3 - Immunology
Catégories WoS
  • 1 - science ; 2 - immunology
  • 1 - science ; 2 - genetics & heredity
Identifiant ISTEX
5C5993D3D7BAA9653BF99E9D85052D46E360F7EA
Revue

Immunogenetics

Année de publication
1993
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
9.34
Sous-corpus
  • Batraciens
  • Mammiferes
  • Oiseaux
Type de publication
Journal
ark:/67375/1BB-9H2VQ2FD-4
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