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Corpus Systématique Animale

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Demonstration of the neural crest origin of type I (APUD) cells in the avian carotid body, using a cytochemical marker system

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  • A. G. E. Pearse 1,2
  • J. M. Polak 1,2
  • F. W. D. Rost 1,2
  • J. Fontaine 1,2
  • C. Le Lièvre 1,2
  • N. Le Douarin 1,2
  • 1) Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
  • 2) Laboratoire d'Embryologie de la Faculté des Sciences de Nantes, Cedex Nantes, France

The biogenic amines present in the carotid body Type 1 cells of two avian species (Japanese quail and chicken) were identified, by microspectrofluorometry of formaldehyde-induced fluorescence, as dopamine and 5-hydroxytryptamine respectively. These and other cytochemical properties establish the cells as members of the APUD series. Grafts of the neural rhombencephalic primordium from 6 to 10-somite quail embryos were implanted in the appropriate region of chick embryos of the same age. After up to 11 days incubation the carotid bodies of the host were freeze-dried and treated with hot formaldehyde vapour. The carotid body Type 1 cells in the chick host were identified, by the presence of dopamine and the absence of 5-HT, as cells from the quail neural crest. The dopamine phenotype in cells of quail origin thus provides a cytochemical marker which may be used for other allograft experiments. The present work confirms earlier findings, using a biological (nuclear chromatin) marker, which showed the avian carotid body to be of neural crest origin.

Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Cell Biology
  • 1 - Health Sciences ; 2 - Health Professions ; 3 - Medical Laboratory Technology
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Molecular Biology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Histology
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