Nom du corpus

Corpus Systématique Animale

Titre du document

Phospholipid transfer proteins: From lipid monolayers to cells

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • Phosphatidylcholine
  • Phosphatidylinositol
  • Fluorescence
  • Photoactivation
  • Lipid binding site
  • PC-TP : phosphatidylcholine transfer protein
  • PI-TP : phosphatidylinositol transfer protein
  • nsL-TP : non specific lipid transfer protein
  • PC : phosphatidylcholine
  • PI : phosphatidylinositol
  • PnA : parinaric acid
Nom du fichier dans la ressource
Mammiferes_v2b_01028
Auteur(s)
  • K. W. A. Wirtz
Affiliation(s)
  • Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Utrecht, The Netherlands
Résumé

Eukaryotic cells contain phospholipid transfer proteins that act as carriers of phospholipids between membranes. In mammalian tissues three transfer proteins with different specificities have been identified: the phosphatidylcholine transfer protein (PC-TP), the phosphatidylinositol transfer protein (PI-TP) and the non-specific lipid transfer protein (nsL-TP) that transfers all common diacyl-phospholipids and cholesterol. Properties of these transfer proteins have been discussed with a special emphasis on the lipid binding site of bovine liver PC-TP. Application of photoactivatable and fluorescent analogues of PC have indicated that PC-TP contains specific and independent hydrophobic binding sites for thesn-1- andsn-2-fatty acyl chains. Because these sites have different properties, PC-TP can discriminate between positional isomers of PC and displays a distinct preference for those molecular species that carry a polyunsaturated fatty acid chain at thesn-2-position. Recent studies on bovine brain PI-TP have strongly suggested that this protein may be well-suited to maintain the levels of PI in natural membranes. Besides this proposed role, evidence has become available from studies on Swiss mouse 3T3 fibroblasts that, apart from its occurrence in cytosol, PI-TP is present in nuclei.

Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
Catégories Scopus
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
Identifiant ISTEX
1C816E3531FF967D55089F7FC4310590D287C778
Revue

Klinische Wochenschrift

Année de publication
1991
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
7.764
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-982GLZFM-L
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