Nom du corpus

Corpus Systématique Animale

Titre du document

Phospholipid transfer proteins: From lipid monolayers to cells

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Springer (journals)
Langue(s) du document
Type de document
Mots-clés d'auteur
  • Phosphatidylcholine
  • Phosphatidylinositol
  • Fluorescence
  • Photoactivation
  • Lipid binding site
  • PC-TP : phosphatidylcholine transfer protein
  • PI-TP : phosphatidylinositol transfer protein
  • nsL-TP : non specific lipid transfer protein
  • PC : phosphatidylcholine
  • PI : phosphatidylinositol
  • PnA : parinaric acid
Nom du fichier dans la ressource
  • K. W. A. Wirtz
  • Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Utrecht, The Netherlands

Eukaryotic cells contain phospholipid transfer proteins that act as carriers of phospholipids between membranes. In mammalian tissues three transfer proteins with different specificities have been identified: the phosphatidylcholine transfer protein (PC-TP), the phosphatidylinositol transfer protein (PI-TP) and the non-specific lipid transfer protein (nsL-TP) that transfers all common diacyl-phospholipids and cholesterol. Properties of these transfer proteins have been discussed with a special emphasis on the lipid binding site of bovine liver PC-TP. Application of photoactivatable and fluorescent analogues of PC have indicated that PC-TP contains specific and independent hydrophobic binding sites for thesn-1- andsn-2-fatty acyl chains. Because these sites have different properties, PC-TP can discriminate between positional isomers of PC and displays a distinct preference for those molecular species that carry a polyunsaturated fatty acid chain at thesn-2-position. Recent studies on bovine brain PI-TP have strongly suggested that this protein may be well-suited to maintain the levels of PI in natural membranes. Besides this proposed role, evidence has become available from studies on Swiss mouse 3T3 fibroblasts that, apart from its occurrence in cytosol, PI-TP is present in nuclei.

Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
Catégories Scopus
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
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Klinische Wochenschrift

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Score qualité du texte
  • Mammiferes
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