Nom du corpus

Corpus Systématique Animale

Titre du document

Lung surfactant phospholipids in different animal species

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Mammiferes_v2b_00642
Auteur(s)
  • Sue A. Shelley 1,2
  • June E. Paciga 1,2
  • John U. Balis 1,2
Affiliation(s)
  • 1) Department of Pathology, University of South Florida Medical Center, 33612, Tampa, PL
  • 2) James A. Haley Veterans Administration Hospital, 33612, Tampa, FL
Résumé

A comparative study of adult mammalian lung surfactants was undertaken to determine which animal species might serve as appropriate models for surfactant alterations in human lung diseases. Phosphatidylcholine (PC) comprised 80–87% of the phospholipid and contained more than 65% palmitic acid in all species studied. Phosphatidylglycerol (PG) was found to vary significantly in fatty acid composition among the species. Rabbit, dog and rat surfactant PG contained 50–60% palmitic acid, while human and cat surfactant contained much lower levels of saturated fatty acids. Both the PC and PG of all species contained 2 positional isomers of fatty acids with 16 carbons and one double bond, but the relative amounts of the unusual isomer, 16?1?7, and palmitoleic, acid, 16?1?9, varied among the different animal species. Only cat and dog surfactant phospholipids contained 18?1?5. Cat surfactant phospholipids also differed by the absence of 20?4 and the presence of small amounts of several 20- and 22-carbon fatty acids. These results explain some discrepancies found in the literature concerning surfactant composition and delineate limiting factors in extrapolating results from animal studies for the evaluation of maturation and pathological alterations in human surfactant.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - nutrition & dietetics
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Cell Biology
  • 1 - Physical Sciences ; 2 - Chemistry ; 3 - Organic Chemistry
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Biochemistry
Catégories WoS
  • 1 - science ; 2 - nutrition & dietetics
  • 1 - science ; 2 - biochemistry & molecular biology
Identifiant ISTEX
C98D481B7318CA98F77BBE00291F49965341E07A
Revue

Lipids

Année de publication
1984
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
8.9
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-7K3R8D5M-P
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