Nom du corpus

Corpus Systématique Animale

Titre du document

The systemic toxicity of Prudhoe Bay crude and other petroleum oils to CD-1 mice

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Oiseaux_v2b_01746
Auteur(s)
  • Frederick A. Leighton
Affiliation(s)
  • Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, S7N 0W0, Saskatoon, SK, Canada
Résumé

CD-1 mice were given oral doses of 0–16 ml/kg/ day for five days of Prudhoe Bay (PBCO), South Louisiana and Arabian Light crude oils, Bunker C oil (BCO), mineral oil (MO) and corn oil. Minor decreases in packed cell volume and increases in mean corpuscular hemoglobin concentration occurred after ingestion of crude oils and BCO. Dietary depletion of vitamin E and selenium failed to enhance hematological changes. Pronounced liver enlargement and atrophy of thymus and spleen accompanied ingestion of all petroleum oils except MO and were shown to be dependent on dose of PBCO. Concentration of RNA and total RNA were increased while total DNA, but not concentration of DNA, was increased in enlarged livers. Liver enlargement was attributed primarily to hyperplasia with an additional contribution due to hypertrophy. The severe hemolytic anemia reported in marine birds that ingested PBCO was not reproduced in mice. Liver enlargement and lymphoid tissue atrophy were similar to those reported in other species exposed to petroleum oils.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - toxicology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences medicales
Catégories Scopus
  • 1 - Physical Sciences ; 2 - Environmental Science ; 3 - Health, Toxicology and Mutagenesis
  • 1 - Physical Sciences ; 2 - Environmental Science ; 3 - Pollution
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - Toxicology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
Catégories WoS
  • 1 - science ; 2 - toxicology
  • 1 - science ; 2 - environmental sciences
Identifiant ISTEX
5D0455A0B3B5E561386E8A7CBB330E7DEB21EAAF
Revue

Archives of Environmental Contamination and Toxicology

Année de publication
1990
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
8.857
Sous-corpus
  • Oiseaux
Type de publication
Journal
ark:/67375/1BB-6L9R1G3N-C
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