Nom du corpus

Corpus Systématique Animale

Titre du document

Inhibitive effects of structurally modified azasteroids and related nitrogen containing steroids on insect growth and development

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Insectes_v2b_01504
Auteur(s)
  • M. J. Thompson 1
  • N. N. Serban 1
  • W. E. Robbins 1
  • J. A. Svoboda 1
  • T. J. Shortino 1
  • S. R. Dutky 1
  • C. F. Cohen 1
Affiliation(s)
  • 1) Insect Physiology Laboratory, Plant Protection Institute, ARS, USDA, 20705, Beltsville, Maryland
Résumé

A number of azasteroids and other nitrogen containing steroids with a modified nucleus or side chain were prepared and tested for their inhibitory effects on the growth and development of several species of insects. Structure-activity studies showed that compounds with a structurally related steroid nucleus and side chain were approximately equal in inhibitory activity for a particular species. The replacement of the tertiary amino group in the side chain of the 5?-steroid with other nitrogen substituents, such as nitro, cyano, acetylamino, or a quaternary ammonium salt, resulted in a considerable loss of inhibitive activity in the tobacco hornworm or the yellowfever mosquito. However, certain modifications of the azasteroid nucleus resulted in compounds that still retained high biological activity. As a result, a compound was synthesized that lacked the A and B rings of the steroid nucleus and that inhibited insect growth, molting, and metamorphosis and the ?24-sterol reductase enzyme system of the tobacco hornworm.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - nutrition & dietetics
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Cell Biology
  • 1 - Physical Sciences ; 2 - Chemistry ; 3 - Organic Chemistry
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Biochemistry
Catégories WoS
  • 1 - science ; 2 - nutrition & dietetics
  • 1 - science ; 2 - biochemistry & molecular biology
Identifiant ISTEX
5E6F6A8E7046DE2935EE765CBA18AB72E1BB080B
Revue

Lipids

Année de publication
1975
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
8.662
Sous-corpus
  • Insectes
Type de publication
Journal
ark:/67375/1BB-62QP79GB-F
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