Nom du corpus

Corpus Systématique Animale

Titre du document

Limited MHC polymorphism in whales

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Mammiferes_v2b_01755
Auteur(s)
  • John Trowsdale 1
  • Vikki Groves 1
  • Alfred Arnason 2
Affiliation(s)
  • 1) Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, WC2A 3PX, London, UK
  • 2) The Blood Bank, The Genetical Division, Reykjavik, Iceland
Résumé

Little is known about disease and genetic variation in aquatic mammalian species such as whales. In this paper human HLA class I and class 11 probes were used to study major histocompatibility complex (MHC) genes from two species of whale: Fin (Balaenoptera physalus) and Sei (B. borealis). Stronger signals were obtained on whale than on equivalent concentrations of mouse DNA. Evidence was obtained for severalDRB-related genes, aDNA gene, oneDQA gene, and multiple class I genes in whales. Interestingly, the whale genes, from the small panel studied, were less polymorphic than those of humans or mice. The aquatic environment of this mammalian species may be a unique factor in shaping its immune response through the MHC.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - immunology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
  • 1 - Life Sciences ; 2 - Immunology and Microbiology ; 3 - Immunology
Catégories WoS
  • 1 - science ; 2 - immunology
  • 1 - science ; 2 - genetics & heredity
Identifiant ISTEX
FF8A9D27148202E70E050FAE00398397B0213527
Revue

Immunogenetics

Année de publication
1989
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
6.393
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-5ZPC4VKL-5
Powered by Lodex 9.3.8