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Corpus Systématique Animale

Titre du document

Some peculiarities of the glucoregulatory response to glucose infusion in the rat

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Springer (journals)
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Type de document
Mots-clés d'auteur
  • Glucose
  • Glucose homeostasis
  • Glucose production
  • Glucose uptake
  • Insulin
  • Metabolic clearance rate of glucose
Nom du fichier dans la ressource
  • Luigi Saccà 1
  • Franco Rengo 1
  • Gavino Perez 1
  • Giuseppe Critelli 1
  • 1) Istituto di Patologia Speciale Medica e Metodologia Clinica dell’Università II Facoltà di Medicina, Via Pansini 5, 80100, Napoli, Italy

The glucoregulatory response to the i.v. infusion of different doses of glucose and glucose plus insulin was studied in anesthetized rats by using the primed constant infusion of glucose-2-3H. Infusion of glucose at the rate of 10 mg/kg/min induced a rise of about 100% in blood glucose, while the hepatic release of glucose showed only a small and transient decrease. A proportional increase of glycemia and glucose utilization (Rd) was observed without any appreciable change in the metabolic clearance rate (MCR) of glucose; a two-fold increase in plasma insulin was recorded at all times. In the group of rats receiving 20 mg/kg/min of glucose, changes in the above parameters were slightly greater; MCR showed a moderate increment in spite of the six-fold rise of plasma insulin. Finally, the infusion of large doses of insulin together with 20 mg/kg/min of glucose resulted in complete cessation of glucose release by the liver and in a remarkable increase of Rd and MCR. These results suggest a poor adaptability of the glucoregulatory system of the rat in response to glucose infusion as compared to other mammalian species.

Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences medicales
  • 4 - endocrinopathies
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Endocrinology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Endocrinology, Diabetes and Metabolism
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Internal Medicine
Identifiant ISTEX

Acta diabetologia latina

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  • Mammiferes
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