Nom du corpus

Corpus Systématique Animale

Titre du document

Rapid evolution of human pseudoautosomal genes and their mouse homologs

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Mammiferes_v2b_02549
Auteur(s)
  • J. W. Ellison 1
  • X. Li 2
  • U. Francke 2,3,4
  • L. J. Shapiro 1
Affiliation(s)
  • 1) Department of Pediatrics, University of California, 94143, San Francisco, California, USA
  • 2) Howard Hughes Medical Institute, Stanford University Medical Center, 94305, Stanford, California, USA
  • 3) Department of Genetics, Stanford University Medical Center, 94305, Stanford, California, USA
  • 4) Department of Pediatrics, Stanford University Medical Center, 94305, Stanford, California, USA
Résumé

Comparative studies of genes in the pseudoautosomal region (PAR) of human and mouse sex chromosomes have thus far been very limited. The only comparisons that can presently be made indicate that the PARs of humans and mice are not identical in terms of gene content. Here we describe additional comparative studies of human pseudoautosomal genes and their mouse homologs. Using a somatic cell hybrid mapping panel, we have assigned the mouse homolog of the human pseudoautosomal inter-leukin 3 receptor alpha subunit (IL3RA) gene to mouse Chromosome (Chr) 14. Attempts to clone the mouse homolog of the human pseudoautosomal adenine nucleotide translocase-3 (ANT3) gene resulted in the isolation of the murine homologs of the human ANT1 and ANT2 genes. The mouse Ant1 and Ant2 genes are very similar in sequence to their human homologs, and we have mapped them to mouse Chromosomes (Chrs) (8 and X respectively) that exhibit conserved synteny with the chromosomes on which the human genes are located. In contrast, the homolog of ANT3 appears to be either very divergent or absent from the mouse genome. Southern blot analysis of DNA from a variety of mammalian species shows restricted conservation of human pseudoautosomal genes, a trend that also applies to the two cloned mouse homologs of these genes and to neighboring human genes in distal Xp22.3. Our observations combined with those of other workers lead us to propose a model for the evolution of the PAR that includes both rapid sequence evolution and the incremental reduction in size of the region during mammalian evolution.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - genetics & heredity
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - genetique des eucaryotes. evolution biologique et moleculaire
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
Catégories WoS
  • 1 - science ; 2 - genetics & heredity
  • 1 - science ; 2 - biotechnology & applied microbiology
  • 1 - science ; 2 - biochemistry & molecular biology
Identifiant ISTEX
C0D38B3D71DFF829516D7EB40A3E173AEB2CAAC4
Revue

Mammalian Genome

Année de publication
1996
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
10
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-5G1HPKWB-B
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