Nom du corpus

Corpus Systématique Animale

Titre du document

Calcium handling in myocardium from amphibian, avian, and mammalian species: the search for two components

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • Aequorin
  • Calcium
  • Sarcoplasmic reticulum
  • Contraction
  • Excitation-contraction coupling
Nom du fichier dans la ressource
Batraciens_v2b_00346, Mammiferes_v2b_01790, Oiseaux_v2b_01899
Auteur(s)
  • Judith K. Gwathmey 1,2,3
  • James P. Morgan 1,2,3
Affiliation(s)
  • 1) Charles A. Dana Research Institute, Harvard Medical School, 02215, Boston, MA, USA
  • 2) Harvard Thorndike Laboratory of Beth Israel Hospital, Department of Medicine, Cardiovascular Division, Harvard Medical School, 02215, Boston, MA, USA
  • 3) Beth Israel Hospital, 02215, Boston, MA, USA
Résumé

Steps involved in excitation-contraction coupling in mammalian myocardium have been derived using a relatively limited number of animal species. However, the use of animal models for investigations into excitation-contraction coupling in normal and disease states has encompassed a wide range of animal species. We addressed the question as to whether excitation-contraction coupling as currently understood applies to intracellular calcium handling in myocardium from multiple mammalian species, amphibian, and avian myocardium. The bioluminescent calcium indicator aequorin was used to record intracellular calcium transients in both ventricular and atrial tissue. We report that in all mammalian and avian species studied the calcium transient recorded in both ventricular and atrial myocardium is monophasic and reflects calcium release and re-uptake by the sarcoplasmic reticulum. In contrast, the Ca2+ transient recorded from salamander myocardium is prolonged relative to mammalian and avian myocardium, and appears to reflect in part trans-sarcolemmal calcium entry. Only in diseased myocardium derived from human and swine myocardium was a second component detected in the calcium transient. These data indicate that sarcoplasmic reticulum calcium handling is pivotal in excitation-contraction coupling for multiple species with differing physiologies. Also, in disease states, intracellular calcium handling is often affected with resultant alterations in the time-course and/or configuration of the calcium transient.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - physiology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Endocrinology
  • 1 - Life Sciences ; 2 - Agricultural and Biological Sciences ; 3 - Animal Science and Zoology
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Biochemistry
  • 1 - Life Sciences ; 2 - Agricultural and Biological Sciences ; 3 - Ecology, Evolution, Behavior and Systematics
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Physiology
Catégories WoS
  • 1 - science ; 2 - zoology
  • 1 - science ; 2 - physiology
Identifiant ISTEX
D6198FB1456D8BEFE2E2BC407F925B197AD9C39E
Revue

Journal of Comparative Physiology B

Année de publication
1991
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
8.585
Sous-corpus
  • Batraciens
  • Mammiferes
  • Oiseaux
Type de publication
Journal
ark:/67375/1BB-5C376DVJ-Q
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