Nom du corpus

Corpus Systématique Animale

Titre du document

Molecular mechanism of null expression of aldehyde dehydrogenase-1 in rat liver

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • aldehyde dehydrogenase
  • isozyme
  • transcriptional regulation
  • tissue-dependent expression
Nom du fichier dans la ressource
Mammiferes_v2b_02078
Auteur(s)
  • James Chen 1
  • Yuchio Yanagawa 1
  • Akira Yoshida 1
Affiliation(s)
  • 1) Department of Biochemical Genetics, Beckman Research, Institute of the City of Hope, 1450 East Duarte Road, 91010, Duarte, California
Résumé

In isozyme systems in general, the pattern of tissue-dependent expression of a given type of isozyme is uniform in various mammalian species. In contrast, a major cytosolic aldehyde dehydrogenase isozyme, termed ALDH1, which is strongly expressed in the livers of humans and other mammals, is hardly detectable in rat liver. Thirteen nucleotides existing in the 5?-promoter region of human, marmoset, and mouseALDH1 genes are absent in the four rat strains examined. When the 13 nucleotides were deleted from a chloramphenicol acetyltransferase expression construct, which contained the 5?-promoter region of the humanALDH1 gene and a low-background promoterless chloramphenicol acetyltransferase expression vector, the expression activity was severely diminished in human hepatic cells. Thus, deletion of the 13 nucleotides in the promoter region of the gene can account for the lack of ALDH1 expression in rat liver.

Catégories Science-Metrix
  • 1 - natural sciences
  • 2 - biology
  • 3 - evolutionary biology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - biochimie analytique, structurale et metabolique
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Molecular Biology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
  • 1 - Life Sciences ; 2 - Agricultural and Biological Sciences ; 3 - Ecology, Evolution, Behavior and Systematics
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Biochemistry
Catégories WoS
  • 1 - science ; 2 - genetics & heredity
  • 1 - science ; 2 - biochemistry & molecular biology
Identifiant ISTEX
8E522138382FDC65651596451657FC408C4A8EA6
Revue

Biochemical Genetics

Année de publication
1996
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
6.174
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-4SR44M81-9
Powered by Lodex 9.3.8