Nom du corpus

Corpus Systématique Animale

Titre du document

In vitro binding of14C-labeled acidic compounds to serum albumin and their tissue distribution in the rat

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • protein binding
  • organic acids
  • tissue distribution
  • species effects
Nom du fichier dans la ressource
Mammiferes_v2b_02838
Auteur(s)
  • S. C. Fang 1
  • F. T. Lindstrom 1
Affiliation(s)
  • 1) Department of Agricultural Chemistry and Department of Statistics, Oregon State University, 97331, Corvallis, OR
Résumé

The acidic compounds, such as phenoxyacetic acids, substituted benzoic acids, or acetylsalicylic acid, were found to bind to bovine serum albumin (BSA). Among phenoxyacetic acids, the binding affinity to BSA was highest for 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), which was approximately 4-, 24-, and 160-fold greater than those for 2,4-dichlorophenoxyacetic acid (2,4-D), o-chlorophenoxyacetic acid (CPA), and phenoxyacetic acid (PAA), respectively. There were two binding sites in BSA for 2,4,5-T and 2,4-D, and one site for others. These acidic compounds also bound to serum albumins of other mammalian species. The binding affinity varied among species and also depended on the chemicals. However, the order of binding affinity in the albumin of each species remained the same as observed in BSA with few exceptions. Blood/tissue ratios of14C from rats dosed with these14C-labeled acids were highly correlated with the logarithm of the binding affinity constants.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - pharmacology & pharmacy
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Pharmacology (medical)
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - General Pharmacology, Toxicology and Pharmaceutics
Identifiant ISTEX
5DD0E2E09848D5BEF0375D8BB73827885C8A679B
Revue

Journal of Pharmacokinetics and Biopharmaceutics

Année de publication
1980
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
7.939
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-4MXFPMRB-Q
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