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Corpus Systématique Animale

Titre du document

Interaction between the sugar and amino-acid transport systems at the small intestinal brush border: A comparative study

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Springer (journals)
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Mots-clés d'auteur
  • Counten-Transport
  • Active Transport
  • Comparative Physiology
  • Amino-Acid and Sugar Transport
  • Interactions between Transport Mechanisms
  • Austausch-Transport
  • Aktiver Transport
  • Vergleichende Physiologie
  • Aminosäure- und Zucker-Transport
  • Wechselwirkungen zwischen Transportmechanismen
Nom du fichier dans la ressource
  • J. W. L. Robinson 1,2
  • F. Alvarado 1,2
  • 1) Departamentos de Farmacología y Fisiología, Facultad de Medicine, Universidad de Puerto Rico, San Juan, Puerto Rico, USA
  • 2) Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela

The interactions between monosacharides and amino-acids for transport by the small intestine have been studied. The experimental approach was specifically designed to try to resolve the controversy concerning the mechanism of such interactions and included a comparative study involving five mammalian species, namely the hamster, the mouse, the guinea-pig, the rat and the rabbit. The results, showing quantitative but no important qualitative differences between the species, provide strong support for the hypothesis that there is an allosteric interaction between the two groups of compounds at the surface of the brush border membrane due to the proximity of their respective binding sites. This theory, which was originally formulated on kinetic evidence obtained with the hamster intestine, is now supported by the following results: The uptake of amino-acids by intestinal rings of all species tested is inhibited by monosaccharides that are substrates for the hexose transport mechanism during short-term incubations. As a corollary, the uptake of sugars is inhibited by neutral amino-acids, but their inhibitory power shows no correlation with their affinities for their own transport mechanism. A stimulation of efflux of amino-acids preloaded into the tissue of everted sacs can be elicited across the brush border by addition of sugars to the bathing medium. The reverse experiment has also been successfully performed. This “counter-transport” effect has been shown to occur in all five species, though it is difficult to demonstrate in the rat, for practical, and perhaps functional, reasons. Additional experiments have also been performed with the specific aim of refuting other theories concerning the mode of interaction between sugars and amino-acids in the small intestine.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - physiology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
Catégories Scopus
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Physiology (medical)
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Clinical Biochemistry
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Physiology
Catégories WoS
  • 1 - science ; 2 - physiology
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  • Mammiferes
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