Nom du corpus

Corpus Systématique Animale

Titre du document

A new isozyme of triose phosphate isomerase specific to hominoids

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • Molecular Evolution
  • Isozymes
  • Gene Duplication
Nom du fichier dans la ressource
Mammiferes_v2b_01833
Auteur(s)
  • H. Rubinson 1
  • M. C. Meienhofer 1
  • J. C. Dreyfus 1
Affiliation(s)
  • 1) Institut de Pathologie Moléculaire, 24, rue du Faubourg Saint-Jacques, 75014, Paris, France
Résumé

1. Electrophoresis of human tissue extracts has indicated a specific pattern in fibroblasts for the enzyme triose phosphate isomerase. In other human tissue extracts only two zones I and II of activity were seen. In fibroblasts extracts a more anodic III band was also visible. 2. Electrophoretic band II was separated from bands I and III. From a study of dissociation by concentrated urea followed by electrophoresis, it was demonstrated that isozyme II is a hybrid between isozymes I and III. An immunological difference was found between isozyme I and II using an antiserum obtained by immunizing rabbits against purified isozyme I. 3. An evolutionary study showed that other mammals and monkeys are lacking the fast bands II and III, while five species of Hominoids (including man) possess them. 4. The tentative conclusion was drawn that isozyme III is made of two? subunits, isozyme I of two? subunits and isozyme II is an?? hybrid. The hypothesis is presented of a gene duplication having appeared at the time of differentiation of Hominoids.

Catégories Science-Metrix
  • 1 - natural sciences
  • 2 - biology
  • 3 - evolutionary biology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Molecular Biology
  • 1 - Life Sciences ; 2 - Agricultural and Biological Sciences ; 3 - Ecology, Evolution, Behavior and Systematics
Catégories WoS
  • 1 - science ; 2 - genetics & heredity
  • 1 - science ; 2 - evolutionary biology
  • 1 - science ; 2 - biochemistry & molecular biology
Identifiant ISTEX
8E3193A779FDFEF58A490184C78E45BC930D9026
Revue

Journal of Molecular Evolution

Année de publication
1973
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
7.681
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-3F6S0JRP-4
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