Nom du corpus

Corpus Systématique Animale

Titre du document

Poly(ADP-ribose) polymerase: Structural conservation among different classes of animals and its implications

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • NAD
  • evolution
  • polymerase chain reaction
  • zinc finger
  • leucine zipper
  • aa : amino acid(s)
  • D. melanogaster : Drosophila melanogaster
  • PARP : poly(ADP-ribose) polymerase [EC 2.4.2.30]
  • PCR : polymerase chain reaction
  • X. laevis : Xenopus laevis
Nom du fichier dans la ressource
Insectes_v2b_01409, Mammiferes_v2b_01993
Auteur(s)
  • Kazuhiko Uchida 1
  • Masanao Miwa 1
Affiliation(s)
  • 1) Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305, Japan
Résumé

Poly(ADP-ribose) polymerase cDNAs have been isolated from different classes of animals. Cloning of genes from lower eukaryotes has allowed us to investigate directly the biological functions of poly(ADP-ribosyl)ationin vivo. The conservation of specific regions among mammals, chicken,Xenopus laevis, andDrosophila melanogaster reveals the essential structural elements required for recognition of breaks in DNA and for catalytic activity. Cys, His and basic residues in the zinc-finger consensus region are conserved. The carboxyl terminal region corresponding to an NAD-binding domain is strongly conserved. The dinucleotide-binding consensus sequence and ?1-?A-?2, Rossmann fold structure, and ?-sheet structures are completely conserved from mammals to insect. InDrosophila, a putative leucine-zipper motif has been identified, and other poly(ADP-ribose) polymerases also contain an ?-helical, amphipathic structure in the auto-modification domain. In this article, we review the recent structural analyses of the functional domains of poly(ADP-ribose) polymerase in phylogenetically divergent species, and discuss the implications of structural conservation for its biological functions.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - biochemistry & molecular biology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Cell Biology
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Clinical Biochemistry
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Molecular Biology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
Catégories WoS
  • 1 - science ; 2 - cell biology
Identifiant ISTEX
29321DBC0CD4B5FE8BB37DB015D5B48631D4415D
Revue

Molecular and Cellular Biochemistry

Année de publication
1994
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
7.13
Sous-corpus
  • Insectes
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-3F0SBXST-H
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