Nom du corpus

Corpus Systématique Animale

Titre du document

Acute toxicities and hematological effects of two substituted naphthoquinones in channel catfish

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Poissons_v2b_002234
Auteur(s)
  • Armando A. Andaya 1
  • Richard T. Di Giulio 1
Affiliation(s)
  • 1) School of Forestry and Environmental Studies, Duke University, 27706, Durham, North Carolina
Résumé

The acute toxicities and hematological effects of menadione (2-methyl-1,4-naphtho-quinone) and dichlone (2,3-dichloro-1,4-naphtho-quinone) were examined in yearling channel catfish (Ictalurus punctatus). These compounds served as models for quinones, which comprise a diverse group of compounds that enter aquatic systems from numerous sources. The 96-hr LC50's measured were 720 ?g/L and 42 ?g/L for menadione and dichlone, respectively. In subsequent experiments, fish were exposed for 21 days to concentrations of 0, 0.25, 0.50, and 0.75 times the LC50 value of each compound. For both compounds, generally dose-dependent increases in methemoglobin concentrations and dose-dependent reductions in hemoglobin concentrations and hematocrit ratios were observed. These results are consistent with the hypothesis that these compounds are toxic in part due to their ability to undergo redox cycling and thereby generate reactive oxygen species. However, other modes of action, such as direct enzyme inhibition, may also be important.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - toxicology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - microbiologie
Catégories Scopus
  • 1 - Physical Sciences ; 2 - Environmental Science ; 3 - Health, Toxicology and Mutagenesis
  • 1 - Physical Sciences ; 2 - Environmental Science ; 3 - Pollution
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - Toxicology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
Catégories WoS
  • 1 - science ; 2 - toxicology
  • 1 - science ; 2 - environmental sciences
Identifiant ISTEX
C8A86F4556D1EB2B1B7BEB2549B7F59A12CEDABE
Revue

Archives of Environmental Contamination and Toxicology

Année de publication
1987
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
8.716
Sous-corpus
  • Poissons
Type de publication
Journal
ark:/67375/1BB-2GJFV5G2-X
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