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Corpus Systématique Animale

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Chromosomal and regional localization of the loci for IGKC, IGGC, ALDB, HOXB, GPT , and PRNP in the American mink ( Mustela vison ): comparisons with human and mouse

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Springer (journals)
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  • T. M. Khlebodarova 1
  • S. N. Malchenko 1
  • N. M. Matveeva 1
  • S. D. Pack 1
  • O. V. Sokolova 1
  • B. Y. Alabiev 1
  • E. S. Belousov 1
  • V. V. Peremislov 1
  • A. M. Nayakshin 1
  • K. Brusgaard 2
  • O. L. Serov 1
  • 1) Laboratory of Developmental Genetics, Institute of Cytology and Genetics, Academy of Russia, Siberian Department, 630090, Novosibirsk 90, Russia
  • 2) Department of Physiology and Biochemistry, National Institute of Animal Sciences, Foulum, Denkmark

Chromosomal localization of the genes for gamma- and kappa-immunoglobulins (IGGC and IGKC, respectively), aldolase B (ALDB), prion protein (PRNP), homeo box B (HOXB), and glutamate pyruvate transaminase (GPT) were determined with the use of mink-rodent hybrid cells. Analysis of segregation of the mink markers and chromosomes in these hybrid cells allowed us to assign the gene for HOXE to Chromosome (Chr) 8, IGGC to Chr 10, PRNP and IGKC to Chr 11, ALDB to Chr 12, and GPT to Chr 14 in mink. Furthermore, using a set of mink-mouse hybrid cells carrying fragments of mink Chr 8 of different sizes, we assigned the gene for HOXB to the pter-p26 region of the short arm of Chr 8. Comparative mapping of the genes of mink, human, and mouse, as well as other mammalian species, demonstrated that the mink genes HOXB, PRNP, ALDB, and IGGC are members of a conserved region shared by many mammalian species in common; the IGKC gene is a member of a conserved region common to carnivores and primates, not rodents; the GPT gene is a member of a syntenic gene group probably unique to the Mustelidae family or carnivores.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - genetics & heredity
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
Catégories WoS
  • 1 - science ; 2 - genetics & heredity
  • 1 - science ; 2 - biotechnology & applied microbiology
  • 1 - science ; 2 - biochemistry & molecular biology
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Mammalian Genome

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  • Mammiferes
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