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Corpus Systématique Animale

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A feline class II ? gene with striking similarity to the HLA-DPA pseudogene

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  • Adrie J. M. Verhoeven 1
  • Marleen H. Roost 2
  • Hidde L. Ploegh 3
  • 1) Department of Biochemistry I, Medical Faculty, Erasmus University, Rotterdam, The Netherlands
  • 2) Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands
  • 3) Department of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands

A genomic library was constructed from DNA of a domestic cat and screened with a human HLA-DR? probe at low stringency. Several positive clones were isolated, and the DNA sequence of one of these clones was determined. Comparison with class II ? gene sequences from other species suggested that the feline gene is a DPA homologue (FLA-DPA) showing 84% similarity with HLA-DP?1 in the exon encoding the second domain. The FLA-DPA gene that was isolated is a pseudogene, as two frame-shift mutations are present: one in the exon encoding the second domain, causing premature termination of translation, and one in the exon encoding the transmembrane region. The latter mutation and the further deletion of two codons in the transmembrane exon show a remarkable resemblance to the same exon of the human pseudogene, HLA-DPA2. Hence, both pseudogenes evolved from the same ancestral gene. The inactivation of this DPA gene could therefore have occurred prior to the major mammalian divergence.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - clinical medicine
  • 3 - immunology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
  • 1 - Life Sciences ; 2 - Immunology and Microbiology ; 3 - Immunology
Catégories WoS
  • 1 - science ; 2 - immunology
  • 1 - science ; 2 - genetics & heredity
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