Nom du corpus

Corpus Systématique Animale

Titre du document

Characterization of a novel human dynein-related gene that is specifically expressed in testis

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Nom du fichier dans la ressource
Echinodermes_v2b_0178
Auteur(s)
  • I. Milisav 1
  • M. H. Jones 1
  • N. A. Affara 1
Affiliation(s)
  • 1) Human Molecular Genetics Group, University of Cambridge Department of Pathology, Tennis Court Road, CB21QP, Cambridge, England, UK
Résumé

A novel dynein-related transcript (designated DNEL1) from human adult testis has been identified that can encode a protein with a size of 91087 Da. The complete nucleotide sequence of the open reading frame is the first to be described for a human dynein-related gene. Northern blot analysis of mRNA from 16 different tissues has shown that DNEL1 is expressed specifically in testis. Analysis of somatic cell hybrids has mapped DNEL1 to Chromosome (Chr) 17. Analysis of a panel of 129 whole genome radiaton hybrid clones including 17q22-q25.3 has placed DNEL1 in 17q distal to the ERBA2L locus. DNEL1 shares a high degree of sequence identity and amino acid similarity with the C-terminal region of the outer arm axonemal dynein ?-heavy chains derived from sea urchin and other species, but not to any gene encoding dynein intermediate or light chains described to date. The close similarity of DNEL1 to the C-terminal part of the axonemal ?-heavy chain may suggest an origin from a common progenitor gene and the testis-specific pattern of expression a possible role in sperm development or motility.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - genetics & heredity
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
Catégories WoS
  • 1 - science ; 2 - genetics & heredity
  • 1 - science ; 2 - biotechnology & applied microbiology
  • 1 - science ; 2 - biochemistry & molecular biology
Identifiant ISTEX
EE00049FBF16D9C6E4A39648BB6C5F01DF738649
Revue

Mammalian Genome

Année de publication
1996
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
9.051
Sous-corpus
  • Echinodermes
Type de publication
Journal
ark:/67375/1BB-0ZWF126S-V
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