Nom du corpus

Corpus Systématique Animale

Titre du document

The comparative acute mammalian toxicity of 1-chloroacetophenone (CN) and 2-chlorobenzylidene malononitrile (CS)

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Research-article
Mots-clés d'auteur
  • Chloroacetophenone
  • 2-Chlorobenzylidene malononitrile
  • Acutetoxicity
  • Skin irritation
  • Sensory irritants
  • Inhalation
Nom du fichier dans la ressource
Mammiferes_v2b_02332
Auteur(s)
  • B. Ballantyne 1
  • D. W. Swanston 1
Affiliation(s)
  • 1) Ministry of Defence, Medical Division, Chemical Defence Establishment, SP4 OJQ, Porton Down, Wiltshire, Great Britain
Résumé

The comparative acute toxicity of two peripheral sensory irritant materials, 1-chloroacetophenone (CN) and 2-chlorobenzylidene malononitrile (CS), has been investigated in several species of small mammal using solutions in polyethylene glycol 300 for intravenous, intraperitoneal and oral administration, and as pure aerosols for inhalation exposure. Additionally, the comparative potency for inducing primary contact dermatitis was studied. CN and CS were found to be about equitoxic by intravenous and intraperitoneal injection, but CS was significantly less toxic by the oral and inhalation routes and less likely to cause non-lethal tissue damage than CN.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - toxicology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences medicales
Catégories Scopus
  • 1 - Physical Sciences ; 2 - Environmental Science ; 3 - Health, Toxicology and Mutagenesis
  • 1 - Life Sciences ; 2 - Pharmacology, Toxicology and Pharmaceutics ; 3 - Toxicology
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
Catégories WoS
  • 1 - science ; 2 - toxicology
Identifiant ISTEX
20B21120C116BAB66B05DA0DAF25AC4EEBFE240E
Revue

Archives of Toxicology

Année de publication
1978
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
8.104
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-0NNHQTPX-K
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