Nom du corpus

Corpus Systématique Animale

Titre du document

Pyruvate dehydrogenase E1? subunit genes in the mouse: Mapping and comparison with human homologs

Lien vers le document
Éditeur
Springer (journals)
Langue(s) du document
Anglais
Type de document
Brief-communication
Nom du fichier dans la ressource
Mammiferes_v2b_01318
Auteur(s)
  • R. M. Brown 1,2
  • H-H. M. Dahl 1
  • G. K. Brown 1,2
Affiliation(s)
  • 1) Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Melbourne, Australia
  • 2) Department of Biochemistry, University of Oxford, Oxford, U.K.
Résumé

Two gene loci for the E1? subunit of the pyruvate dehydrogenase (PDH) complex have been mapped in the mouse by in situ hybridization. One locus maps to the X chromosome in the region F3–F4, the other to chromosome 19, in band B close to the centromere. This arrangement is exactly comparable to the situation in man where there is an X-linked PDH E1? locus and an autosomal locus on chromosome 4. Comparison of the regional localization of the human and mouse X-linked PDH E1? genes provides further information concerning sites of rearrangement of segments of the X chromosome during mammalian evolution. The human autosomal PDH E1? gene is a “processed” gene, which lacks the introns that are present in the X-linked gene. It codes for a testis-specific E1? subunit that is only expressed after the onset of spermatogenesis. The comparative mapping results in the mouse suggest that the genetic organization and pattern of expression of the two PDH E1? genes is the same in the two species.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - developmental biology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences biologiques fondamentales et appliquees. psychologie
  • 4 - psychologie. psychophysiologie
Catégories Scopus
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Cell Biology
  • 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics
Identifiant ISTEX
B9EA545416D3B69C02CCCBD4546D910C15028B87
Revue

Somatic Cell and Molecular Genetics

Année de publication
1990
Présence de XML structuré
Non
Version PDF
1.3
Score qualité du texte
6.366
Sous-corpus
  • Mammiferes
Type de publication
Journal
ark:/67375/1BB-0J58TGC6-C
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