Pyruvate dehydrogenase E1? subunit genes in the mouse: Mapping and comparison with human homologs
- 1) Murdoch Institute for Research into Birth Defects, Royal Children's Hospital, Melbourne, Australia
- 2) Department of Biochemistry, University of Oxford, Oxford, U.K.
Two gene loci for the E1? subunit of the pyruvate dehydrogenase (PDH) complex have been mapped in the mouse by in situ hybridization. One locus maps to the X chromosome in the region F3–F4, the other to chromosome 19, in band B close to the centromere. This arrangement is exactly comparable to the situation in man where there is an X-linked PDH E1? locus and an autosomal locus on chromosome 4. Comparison of the regional localization of the human and mouse X-linked PDH E1? genes provides further information concerning sites of rearrangement of segments of the X chromosome during mammalian evolution. The human autosomal PDH E1? gene is a “processed” gene, which lacks the introns that are present in the X-linked gene. It codes for a testis-specific E1? subunit that is only expressed after the onset of spermatogenesis. The comparative mapping results in the mouse suggest that the genetic organization and pattern of expression of the two PDH E1? genes is the same in the two species.
- 1 - sciences appliquees, technologies et medecines
- 2 - sciences biologiques et medicales
- 3 - sciences biologiques fondamentales et appliquees. psychologie
- 4 - psychologie. psychophysiologie
- 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Cell Biology
- 1 - Life Sciences ; 2 - Biochemistry, Genetics and Molecular Biology ; 3 - Genetics